International Journal Software Engineering and Computer Science (IJSECS), Vol. 5 No. 3 (December 2025), showcases advanced research bridging artificial intelligence, healthcare technology, and intelligent system architectures across diverse sectors. Machine learning implementations span Vision Transformer methods for mosquito larvae classification in disease surveillance, Explainable Boosting Machine algorithms for employee burnout prediction, and hybrid ARIMA-LSTM models for financial forecasting. Healthcare information systems demonstrate maturity through Python Tkinter-based patient referral platforms, RAD methodology applications in hospital education systems, and Agile implementations for medical record review processes, while Health-LLM Agent methods innovatively integrate Traditional Chinese Medicine with contemporary AI for acupuncture recommendations. Computer vision technologies address practical challenges from Tesseract OCR optimization for Indonesian ID card processing to Haar Cascade facial recognition securing warehouse access. Natural language processing advances through voice-to-text meeting transcription systems and sentiment analysis applications in educational institutions. IoT architectures evolve through automated health measurement systems, N8N platform implementations in smart farming, and Flutter-Firebase mobile applications for vital sign monitoring. Cybersecurity research addresses sophisticated threats through Zero Trust Architecture integration with blockchain technology, Advanced Persistent Threats analysis, and super encryption implementations for governmental data protection. Decision support systems employ Decision Tree algorithms for athletic talent identification and K-Means clustering for waste management optimization. Software development methodologies range from Design Thinking approaches optimizing user interfaces to Extreme Programming implementations in mortality reporting systems. Apache Spark applications in business data engineering, Bayesian simulation for autonomous vehicle risk analysis, and GIS applications in community empowerment initiatives demonstrate the field's expanding scope, positioning IJSECS as a valuable resource addressing real-world technological challenges with rigorous methodology and practical applicability.